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Many of the lawsuits allege that Takeda either knew or really should have known the long-term effects of the drug, primarily the increased probability of bladder cancer in those taking higher dosages or taking Actos on an extended amount of time. Although the FDA had previously rejected Takeda's application for alogliptin in June 2009, it absolutely was approved in Japan a year ago and is marketed under the name Nesina, and Takeda has since resubmitted applications for both alogliptin and a combination therapy with Actos after the federal government here required more safety testing. Rios alleged in their own lawsuit that the manufacturer (Takeda Pharmaceuticals Ltd. For this reason, most doctors found it trustworthy and therefore prescribed it for their patients as soon being a physical examination had been carried out.

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